CSS grid in Internet Explorer 11
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Jeremy Keith:

Frankly, the whole point of prefixed CSS is that is not used after a reasonable amount of time (originally, the idea was that it would not be used in production, but that didn’t last long). As we’ve moved away from prefixes to flags in browsers, I’m seeing the amount of prefixed properties dropping, and that’s very, very good. I’ve stopped using autoprefixer on new projects, and I’ve been able to remove it from some existing ones—please consider doing the same.

Browser prefixes seem to be slowly going away. I stopped using Autoprefixer last year and haven’t missed it.