Jeremy Keith:

Where it gets interesting is when a technology that’s designed for developer convenience is made out of the very materials being delivered to users. For example, a CSS framework like Bootstrap is made of CSS. That’s different to a tool like Sass which outputs CSS. Whether or not a developer chooses to use Sass is irrelevant to the user—the final output will be CSS either way. But if a developer chooses to use a CSS framework, that decision has a direct impact on the user experience. The user must download the framework in order for the developer to get the benefit.

So whereas Sass sits at the back of the front end—where I don’t care what you use—Bootstrap sits at the front of the front end. For tools like that, I don’t think saying “use whatever works for you” is good enough. It’s got to be weighed against the cost to the user.